發布於 2017-12-04
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  • 00:57 1.
    index 1
  • 09:11 2.
    CHAPTER 12 Pharmacogenetics and Drug Metabolism
  • 03:08 3.
    Examples
  • 03:40 4.
    Examples
  • 02:20 5.
    Slide 4
  • 02:04 6.
    Clinical Outcome
  • 01:00 7.
    Pharmacodynamics and Drug Response
  • 00:59 8.
    Pharmacokinetics
  • 00:47 9.
    Molecular and Cellular Functional Assays
  • 00:54 10.
    Genotype
  • 04:46 11.
    Introduction
  • 01:39 12.
    Introduction
  • 01:42 13.
    Introduction
  • 01:40 14.
    Variation in drug response
  • 01:01 15.
    Variation in drug response
  • 00:32 16.
    Variation in drug response
  • 02:59 17.
    Genetic polymorphisms
  • 03:56 18.
    Most drug-metabolizing enzymes
  • 03:15 19.
    Pharmacogenomics
  • 04:43 20.
    Adverse drug reactions
  • 02:18 21.
    Genetic polymorphism affecting drug response/side effect
  • 00:01 22.
    Genetic polymorphism affecting drug response/side effect
  • 00:03 23.
    Genetic polymorphism affecting drug response/side effect
  • 03:56 24.
    Genetic polymorphism in drug metabolism: CYP isozymes
  • 01:06 25.
    Genetic polymorphism in drug metabolism: CYP isozymes
  • 01:12 26.
    Genetic polymorphism in drug metabolism: CYP isozymes
  • 04:10 27.
    Genetic polymorphism in drug transport: P-gp and MDR
  • 01:56 28.
    Genetic polymorphism in drug transport: P-gp and MDR
  • 04:42 29.
    Genetic polymorphism in drug targets
  • 00:04 30.
    Genetic polymorphism in drug targets
  • 12:40 31.
    Genetic polymorphism in drug targets
  • 01:25 32.
    ** after 2017-CHAPTER 12.ppt
  • 04:03 33.
    CHAPTER 13Physiologic Factors Related to Drug Absorption
  • 00:03 34.
    ** after 2017-CHAPTER 13.ppt
  • 12:26 35.
    CHAPTER 13Physiologic Factors Related to Drug Absorption
  • 04:10 36.
    Drug absorption
  • 09:16 37.
    Nature of the cell membrane
  • 09:44 38.
    Passage of drugs across cell membranes
  • 03:25 39.
    Passage of drugs across cell membranes
  • 01:44 40.
    Passage of drugs across cell membranes
  • 00:44 41.
    Passage of drugs across cell membranes
  • 00:43 42.
    Passage of drugs across cell membranes
  • 00:02 43.
    Passage of drugs across cell membranes
  • 01:36 44.
    Passage of drugs across cell membranes
  • 10:48 45.
    Oral drug absorption
  • 02:18 46.
    Oral drug absorption
  • 02:03 47.
    Methods for studying factors that affect drug absorption
  • 01:45 48.
    Methods for studying factors that affect drug absorption
  • 01:40 49.
    Methods for studying factors that affect drug absorption
  • 01:18 50.
    Methods for studying factors that affect drug absorption
  • 03:02 51.
    Methods for studying factors that affect drug absorption
  • 03:02 52.
    Methods for studying factors that affect drug absorption
  • 00:00 53.
    Methods for studying factors that affect drug absorption
  • 00:00 54.
    Methods for studying factors that affect drug absorption
  • 00:00 55.
    Methods for studying factors that affect drug absorption
  • 00:00 56.
    Methods for studying factors that affect drug absorption
  • 00:00 57.
    Methods for studying factors that affect drug absorption
  • 00:00 58.
    Oral drug absorption
  • 00:00 59.
    Oral drug absorption
  • 00:13 60.
    Passage of drugs across cell membranes
  • 00:00 61.
    Passage of drugs across cell membranes
  • 00:20 62.
    Passage of drugs across cell membranes
  • 00:00 63.
    Passage of drugs across cell membranes
  • 00:00 64.
    Passage of drugs across cell membranes
  • 00:00 65.
    Oral drug absorption
  • 00:00 66.
    Oral drug absorption
  • 00:00 67.
    Methods for studying factors that affect drug absorption
  • 00:00 68.
    Methods for studying factors that affect drug absorption
  • 00:00 69.
    Methods for studying factors that affect drug absorption
  • 00:01 70.
    Methods for studying factors that affect drug absorption
  • 00:01 71.
    Methods for studying factors that affect drug absorption
  • 00:03 72.
    Methods for studying factors that affect drug absorption
  • 03:58 73.
    Methods for studying factors that affect drug absorption
  • 01:51 74.
    Methods for studying factors that affect drug absorption
  • 01:39 75.
    Effect of disease states on drug absorption
  • Index
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